Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in dimeric form
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8kdb
Q-score: 0.577
Xie J, Ouizougun-Oubari M, Wang L, Zhai G, Wu D, Lin Z, Wang M, Ludeke B, Yan X, Nilsson T, Gao L, Huang X, Fearns R, Chen S
Nat Commun (2024) 15 pp. 3163-3163 [ DOI: doi:10.1038/s41467-024-47470-7 Pubmed: 38605025 ]
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (260 kDa, Protein from Human respirovirus 3)
- Magnesium ion (24 Da, Ligand)
- Human parainfluenza virus hpiv3 l-p polymerase in dimeric form (Complex from Human respirovirus 3)
- Phosphoprotein (68 kDa, Protein from Human respirovirus 3)
Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in monomeric form
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8kdc
Q-score: 0.506
Xie J, Ouizougun-Oubari M, Wang L, Zhai G, Wu D, Lin Z, Wang M, Ludeke B, Yan X, Nilsson T, Gao L, Huang X, Fearns R, Chen S
Nat Commun (2024) 15 pp. 3163-3163 [ DOI: doi:10.1038/s41467-024-47470-7 Pubmed: 38605025 ]
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (260 kDa, Protein from Human respirovirus 3)
- Magnesium ion (24 Da, Ligand)
- Phosphoprotein (68 kDa, Protein from Human respirovirus 3)
- Human parainfluenza virus hpiv3 l-p polymerase in monomeric form (Complex from Human respirovirus 3)
Structure Of Respiratory Syncytial Virus Polymerase with Novel Non-Nucleoside Inhibitor
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8fu3
Q-score: 0.523
Yu X, Abeywickrema P, Bonneux B, Behera I, Anson B, Jacoby E, Fung A, Adhikary S, Bhaumik A, Carbajo RJ, De Bruyn S, Miller R, Patrick A, Pham Q, Piassek M, Verheyen N, Shareef A, Sutto-Ortiz P, Ysebaert N, Van Vlijmen H, Jonckers THM, Herschke F, McLellan JS, Decroly E, Fearns R, Grosse S, Roymans D, Sharma S, Rigaux P, Jin Z
Commun Biol (2023) 6 pp. 1074-1074 [ DOI: doi:10.1038/s42003-023-05451-4 Pubmed: 37865687 ]
- Structure of respiratory syncytial virus polymerase with novel non-nucleoside inhibitor (Complex from Human respiratory syncytial virus A2)
- 8-methoxy-3-methyl-n-{(2s)-3,3,3-trifluoro-2-[5-fluoro-6-(4-fluorophenyl)-4-(2-hydroxypropan-2-yl)pyridin-2-yl]-2-hydroxypropyl}cinnoline-6-carboxamide (576 Da, Ligand)
- Phosphoprotein (29 kDa, Protein from Human respiratory syncytial virus A2)
- Rna-directed rna polymerase l (254 kDa, Protein from Human respiratory syncytial virus A2)
Co-structure of the Respiratory Syncytial Virus RNA-dependent RNA polymerase with MRK-1
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8fpi
Q-score: 0.603
Kleiner VA, Fischmann TO, Howe JA, Beshore DC, Eddins MJ, Hou Y, Mayhood T, Klein D, Nahas DD, Lucas BJ, Xi H, Murray E, Ma DY, Getty K, Fearns R
Commun Biol (2023) 6 pp. 649-649 [ DOI: doi:10.1038/s42003-023-04990-0 Pubmed: 37337079 ]
- 4-(2-aminopropan-2-yl)-n'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide (478 Da, Ligand)
- Rna-directed rna polymerase l (173 kDa, Protein from Human respiratory syncytial virus A2)
- Respiratory syncytial virus polymerase (l) protein bound by the tetrameric phosphoprotein (p) and complexed with mrk-1 (Complex from Human orthopneumovirus)
- Phosphoprotein (29 kDa, Protein from Human respiratory syncytial virus A2)
Co-structure of the Human Metapneunomovirus RNA-dependent RNA polymerase with MRK-1
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8fpj
Q-score: 0.566
Kleiner VA, Fischmann TO, Howe JA, Beshore DC, Eddins MJ, Hou Y, Mayhood T, Klein D, Nahas DD, Lucas BJ, Xi H, Murray E, Ma DY, Getty K, Fearns R
Commun Biol (2023) 6 pp. 649-649 [ DOI: doi:10.1038/s42003-023-04990-0 Pubmed: 37337079 ]
- 4-(2-aminopropan-2-yl)-n'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide (478 Da, Ligand)
- Rna-directed rna polymerase l (235 kDa, Protein from Human metapneumovirus)
- Human metapneumovirus polymerase (l) protein bound by the tetrameric phosphoprotein (p) and complexed with mrk-1 (Complex from Human metapneumovirus CAN97-83)
- Phosphoprotein (34 kDa, Protein from Human metapneumovirus)
Tomogram of respiratory syncytial virus filamentous virion
Conley MJ, Short JM, Burns AM, Streetley J, Hutchings J, Bakker SE, Power BJ, Jaffery H, Haney J, Zanetti G, Murcia PR, Stewart M, Fearns R, Vijayakrishnan S, Bhella D
EMBO J (2022) 41 pp. e109728-e109728 [ Pubmed: 34935163 DOI: doi:10.15252/embj.2021109728 ]
Structure of respiratory syncytial virus matrix layer
Conley MJ, Short JM, Burns AM, Streetley J, Hutchings J, Bakker SE, Power BJ, Jaffery H, Haney J, Zanetti G, Murcia PR, Stewart M, Fearns R, Vijayakrishnan S, Bhella D
EMBO J (2022) 41 pp. e109728-e109728 [ Pubmed: 34935163 DOI: doi:10.15252/embj.2021109728 ]
Structure of the Human Metapneumovirus Polymerase bound to the phosphoprotein tetramer
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6u5o
Q-score: 0.437
Pan J, Qian X, Lattmann S, El Sahili A, Yeo TH, Jia H, Cressey T, Ludeke B, Noton S, Kalocsay M, Fearns R, Lescar J
Nature (2020) 577 pp. 275-279 [ Pubmed: 31698413 DOI: doi:10.1038/s41586-019-1759-1 ]
- Human metapneumovirus can97-83 (360 kDa, Complex from Human metapneumovirus CAN97-83)
- Rna-directed rna polymerase l (233 kDa, Protein from Human metapneumovirus (strain CAN97-83))
- Phosphoprotein (35 kDa, Protein from Human metapneumovirus (strain CAN97-83))